Reassessing diabetes and APOE genotype as potential interacting risk factors for Alzheimer’s disease

Ravipati, Kaushik, Chen, Yunxiao and Manns, Joseph R. (2022) Reassessing diabetes and APOE genotype as potential interacting risk factors for Alzheimer’s disease. American Journal of Alzheimer's Disease and other Dementias, 37. 1 - 10. ISSN 1533-3175

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Abstract

Objective: To assess whether diabetes alone or in association with Apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer’s Disease (AD) diagnosis. Methods: A retrospective cohort study of 33,456 participants from the National Alzheimer’s Coordinating Center database. Results: Participants with one or two APOE ε4 alleles had 2.71 (CI:2.55–2.88) and 9.37 (CI:8.14–10.78) times higher odds of AD diagnosis, respectively, relative to those with zero ε4 alleles. In contrast, diabetic participants showed 1.07 (CI:0.96–1.18) times higher odds of AD relative to nondiabetics. Diabetes did not exacerbate the odds of AD in APOE ε4 carriers. APOE ε4 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. However, diabetes was correlated with working memory decline, which had a relatively weak correlation with AD. Conclusions: Unlike APOE ε4, there was little evidence that diabetes was a risk factor for AD.

Item Type:	Article
Official URL:	https://journals.sagepub.com/home/aja
Additional Information:	© 2022 The Authors
Divisions:	Statistics
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine H Social Sciences > HA Statistics
Date Deposited:	02 Feb 2022 17:57
Last Modified:	20 Sep 2025 02:08
URI:	http://eprintstest.lse.ac.uk/id/eprint/113607

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